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Twenty-five thousand marathon men and women will gather at Dodgers Stadium for the start on Sunday morning.
Wrestler-turned-film star Dwayne Johnson and actress Julia Louis-Dreyfuss will be among the stars cheering on the runners at checkpoints along the route.
Last year's (09) marathon winner, Kenyan Wesley Korir, is the man to beat again. Reality TV star Andy Baldwin is expected to be the first celebrity to cross the finish line in Santa Monica, California.