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The night's big loser was The King's Speech, which led all nominations with seven, but went home with only one - a Best Actor gong for Oscars favorite Colin Firth.

The ceremony's highlight came when Michael Douglas took the stage at the Beverly Hilton Hotel to hand out the Best Motion Picture (Drama) award a week after announcing he was winning his cancer battle.

The healthy looking movie veteran received a standing ovation and then joked, "There's gotta be an easier way of getting a standing ovation... I'm very very happy to be here tonight."

Alongside Firth, Paul Giamatti (Barney's Version), Annette Bening (The Kids Are All Right) and Natalie Portman (Black Swan) won the night's top acting awards for comedy and dramatic movies, while Christian Bale and Melissa Leo claimed the Best Supporting Actor and Actress drama prizes for their roles in boxing drama The Fighter.

In the TV categories, Glee and Boardwalk Empire were the only multiple winners - Glee claimed Best Comedy or Musical Series, while stars Jane Lynch and Chris Colfer won acting honors. Boardwalk Empire was named Best Drama Series and its star Steve Buscemi landed a Best Actor prize.

Other TV acting honors went to Claire Danes, Al Pacino, Jim Parsons, Katey Sagal and Laura Linney.

The full list of winners is:

Best Motion Picture (Drama) - The Social Network

Best Performance by an Actress in a Motion Picture (Drama) - Natalie Portman (Black Swan)

Best Performance by an Actor in a Motion Picture (Drama) - Colin Firth (The King's Speech)

Best Motion Picture (Comedy Or Musical) - The Kids Are All Right

Best Performance by an Actress in a Motion Picture (Comedy Or Musical) - Annette Bening (The Kids Are All Right)

Best Performance by an Actor in a Motion Picture (Comedy Or Musical) - Paul Giamatti (Barney's Version)

Best Performance by an Actress In A Supporting Role in a Motion Picture - Melissa Leo (The Fighter)

Best Performance by an Actor In A Supporting Role in a Motion Picture - Christian Bale

Best Animated Feature Film - Toy Story 3

Best Foreign Language Film - In a Better World (Denmark)

Best Director - David Fincher (The Social Network)

Best Screenplay - Aaron Sorkin (The Social Network)

Best Original Score - The Social Network by Trent Reznor & Atticus Ross

Best Original Song - You Haven't Seen The Last of Me by Diane Warren/Cher (Burlesque)

Best Television Series (Drama) - Boardwalk Empire

Best Performance by an Actress In A Television Series (Drama) - Katey Sagal (Sons of Anarchy)

Best Performance by an Actor In A Television Series (Drama) - Steve Buscemi (Boardwalk Empire)

Best Television Series (Comedy Or Musical) - Glee

Best Performance by an Actress In A Television Series (Comedy Or Musical) - Laura Linney (The Big C)

Best Performance by an Actor In A Television Series (Comedy Or Musical) - Jim Parsons (The Big Bang Theory)

Best Mini-Series Or Motion Picture Made for Television - Carlos

Best Performance by an Actress In A Mini-series or Motion Picture Made for Television - Claire Danes (Temple Grandin)

Best Performance by an Actor in a Mini-Series or Motion Picture Made for Television - Al Pacino (You Don't Know Jack)

Best Performance by an Actress in a Supporting Role in a Series, Mini-Series or Motion Picture Made for Television - Jane Lynch (Glee)

Best Performance by an Actor in a Supporting Role in a Series, Mini-Series or Motion Picture Made for Television - Chris Colfer (Glee)

Cecil B. DeMille Award - Robert De Niro