Ne-Yo will appear in the strip as a man called Jerome who is given superpowers but is banned from falling in love.
The collaboration will also see the singer's first three singles from the album - Beautiful Monster, Champagne Life and One in a Million - turned into animated videos to continue the comic book story.
Ne-Yo tell Britain's Daily Star, "I've been a fan (of Lee's) for years. I'm trying not to geek-out being with Stan. It's cool that I can take this comic element of myself and blend it into the R&B element. I got to draw characters myself."
Lee adds, "A really good rapper inspires people. Reading a good comic book does the same thing."
Libra Scale is due for release later this month (Oct10).