The pair spent four months on the road travelling from London to New York and covered a cumulative distance of 22,345 miles (35,960 kilometres).
They filmed the trip for their Long Way Round television series, which also spawned a bestselling book of the same name.
Now McGregor wants to do it all again - he's planning more adventures for this summer (10) after a family vacation with his wife, Eve Mavrakis, and their children.
He says, "I've done a lot of hard work recently and I admit that after a burst of intense creativity I've got a bit of wanderlust. I've still got the bike and it's now got a sidecar on it, so I'll take my dog Sid along with me this time.
"I want to have our summer holidays as a family and then I'd like to get going. It would be a fantastic thing to do. It'll be good to get my leathers and my goggles on again."