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In the album category, he'll be fighting it out against Arcade Fire, Lady Antebellum, Lady Gaga and Katy Perry, while his competition for Song of the Year includes Miranda Lambert and Cee Lo Green.
However, despite his 10 nods, Eminem can only scoop a maximum of nine trophies - in the Best Rap Song category, Love The Way You Lie and his solo track Not Afraid are both nominated.
Eminem was revealed as the frontrunner during Wednesday night's (01Dec10) Grammy Nominations Concert in Los Angeles, which saw Katy Perry kick off the show with a performance of California Gurls on the L.A. Live Plaza.
Perry received a string of top honours herself: she'll face chart rival Lady Gaga in categories including Album Of The Year, Best Female Pop Vocal Performance, Best Pop Collaboration With Vocals and Best Pop Vocal Album.
Miranda Lambert dominates the country award categories, while Bruno Mars, Beyonce, Lady Antebellum and Cee Lo Green are also celebrating after receiving multiple nominations.
A surprise nod comes in the Best Male Pop Vocal Performance section - the late Michael Jackson is nominated for his track This Is It, which faces Michael Buble, Adam Lambert, Bruno Mars and John Mayer in the category.
The Grammy Awards will take place at the Staples Center in Los Angeles on 13 February (11).