Meanwhile, country music trio Lady A will compete for favourite country album, favourite adult contemporary artist, the breakthrough artist award prize and favourite band, duo or group in the pop/rock and country categories.
Canadian teen idol Justin Bieber follows the pair with four nods including best breakthrough artist, while Usher, Katy Perry, hip-hop singer B.o.B, and pop newcomer Ke$ha collected three nominations each.
Lady Gaga earned two nominations, including one for the coveted artist of the year award - a category which will see her face-off against Bieber, Perry, Ke$ha and Eminem.
Winners will be determined by online voting.
The 38th annual American Music Awards will be televised from Los Angeles on 21 November (10).