Beyonce admits the role will be especially poignant as she fell in love with Streisand's voice during screenings of the movie with her mother when she was a young girl.
She tells Reuters, "It's when I became a fan of Barbra Streisand's. And I then saw Judy Garland's version of A Star Is Born and I realised every 20 to 30 years a new star is born and a new talent represents that generation and era - so I didn't think that I would ever get the opportunity to be the star."
Despite her stellar previous success, Beyonce has hailed this movie role as "the biggest opportunity" of her life, and can't believe Eastwood chose her to front the film.
She adds, "I met with Clint and I was so nervous and I know that it is the biggest opportunity of my life. I will work as hard as I can. Because I can't wait. And I am so happy that he trusts me and I am in good hands and I am so fortunate."